Pagano back to coach Colts after cancer treatment

 Chuck Pagano stepped to the podium Monday, hugged his team owner, thanked his family for its support and wiped a tear from his eye.
He might, finally, turn out the lights in his office, too.
Nearly three months to the day after being diagnosed with leukemia, the Colts' first-year coach returned to a team eager to reunite with a boss healthy enough to go back to work.
"I told you my best day of my life was July 1, 1989," Pagano said, referring to his wedding date. "Today was No. 2. Getting to pull up, drive in, get out of my car, the key fob still worked. I was beginning to question whether it would or not. When I asked for Bruce to take over, I asked for him to kick some you-know-what and to do great. Damn Bruce, you had to go and win nine games? Tough act to follow. Tough act to follow. Best in the history of the NFL. That's what I have to come back to."
The comment turned tears into the laughter everyone expected on such a festive occasion.
For Pagano and the Colts, Monday morning was as precious as anyone could have imagined when Pagano took an indefinite leave to face the biggest opponent of his life, cancer.
In his absence, all the Colts was win nine of 12 games, make a historic turnaround and clinch a playoff spot all before Sunday's regular-season finale against Houston, which they pegged as the day they hoped to have Pagano back. If all goes well at practice this week, Pagano will be on the sideline for the first time since a Week 3 loss to Jacksonville.
Pagano endured three rounds of chemotherapy to put his cancer in remission.
That Pagano's return came less than 24 hours after Indy (10-5) locked up the No. 5 seed in the AFC and the day before Christmas seemed fitting, too.
"I know Chuck is ready for this challenge. In speaking to his doctor multiple times, I know that the time is right for him to grab the reins, get the head coaching cap on and begin the journey," owner Jim Irsay said. "It's been a miraculous story. It really is a book. It's a fairytale. It's a Hollywood script. It's all those things but it's real."
The reality is that he's returning to a vastly different team than the one he turned over to Arians, his long-time friend and first assistant coaching hire.
Back then, the Colts were 1-2 and most of the so-called experts had written them off as one of the league's worst teams. Now, they're ready to show the football world that they can be just as successful under Pagano as they were under Arians, who tied the NFL record for wins after a midseason coaching change.
Pagano also has changed.
The neatly-trimmed salt-and-pepper hair and trademark goatee that were missing in November have slowly returned, and the thinner man who appeared to be catching his breath during a postgame speech in early November, looked and sounded as good as ever Monday.
He repeatedly thanked fans for their prayers and letters, the organization and his family for their unwavering help and promised to provide comfort and support to other people who are facing similar fights. During one poignant moment that nearly brought out tears again, Pagano even recounted a letter sent to him by a 9-year-old child who suggested he suck on ice chips and strawberry Popsicles in the hospital and advised him to be nice to the nurses regardless of how he felt — and he never even paused.
"I feel great, my weight is back, my energy is back and again, it's just a blessing to be back here," Pagano said.
In the minds of Colts players and coaches, Pagano never really left.
He continually watched practice tape and game film on his computer, used phone calls and text messages to regularly communicate with players and occasionally delivered a pregame or postgame speech to his team.
"He texted me and called me so much, it was like he was standing there in my face every day," said receiver Reggie Wayne, who has been friends with Pagano since the two were working together at the University of Miami.
But the Colts found plenty of other ways to keep Pagano's battle in the forefront.
They began a fundraising campaign for leukemia research, calling it Chuckstrong. Players had stickers with the initials CP on their locker room nameplates, and Arians wore an orange ribbon on his baseball cap during games. Orange is the symbolic color for leukemia. At one point, nearly three dozen players shaved their heads to show their ailing coach they were with him.
That's not all.
Arians and first-year general manager Ryan Grigson decided to leave the lights on in Pagano's office until he returned. Pagano noted the team even installed plastic clips to make sure those lights were not mistakenly turned off while he was gone. Those clips were removed when Pagano arrived Monday morning.
And Arians said nobody sat in the front seat of the team bus.
"He's always been our head coach," Arians said.
So after getting medical clearance from his oncologist, Dr. Larry Cripe, to return with no restrictions, Pagano couldn't wait to get to the office Monday morning.
Arians arrived at 7 a.m., three hours early for the scheduled team meeting. By then, Pagano had already driven past the inflatable Colts player with the words "Welcome Back Chuck" printed on its chest and was back in his office preparing for the Texans.
Players showed up a couple of hours later, and when the torch was passed from Arians back to Pagano, players gave their returning coach a standing ovation that Wayne said was well-deserved.
All Pagano wants to do now is emulate the success Arians and his players have had this season.
"I asked him (Arians) if he would lead this team and this ballclub and this organization and take over the reins," Pagano said. "What a masterful, masterful job you did Bruce. You carried the torch and all you went out and did was win nine ballgames. You got us our 10th win yesterday and you got us into the playoffs. You did it with dignity and you did it with class. You're everything that I always knew you were and more.

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Pagano joins playoff bound Colts after battle with cancer

The Indianapolis Colts and their fans got an early Christmas gift when head coach Chuck Pagano returned to work on Monday, three months after being forced to the sidelines to battle cancer.
Diagnosed with leukemia in late September, Pagano spent the last three months undergoing treatment, including chemotherapy, while his inspired team led by rookie quarterback Andrew Luck battled on the field earning an unlikely playoff spot.
"Circumstances don't make you, they reveal you," an emotional Pagano told reporters after reporting for work at the teams Indianapolis training facility. "The way I look at it is, my job has just begun.
"Besides my job here...my job now is to give back everything I can possibly give back to everyone out there who's fighting some type of illness, some type of disease, some type of cancer."
The Colts, who tied for the NFL's worst record last season at 2-14, improved to 10-5 with their win over the Kansas City Chiefs on Sunday clinching an AFC wild card.
After three games into a rebuilding season, the Colts learned Pagano would take indefinite leave to fight his cancer and was replaced by assistant coach and offensive coordinator Bruce Arians.
The goal of the Colts became to keep playing until Pagano could return to work.
Indianapolis went 9-3 under Arians, who will hand over the head coaching job back to Pagano for the regular season finale this Sunday against the Houston Texans.
"It's a fairy tale," said Colts owner Jim Irsay. "It's a Hollywood script. But it's real.

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Medical abortions are safe: study

- Less than one percent of women getting a medication-induced abortion at Planned Parenthood had a serious side effect or a failed abortion, according to a new study. Researchers found the rate of abortion-related complications sending women to the emergency room or requiring a blood transfusion, for example, was one in 625 during 2009 and 2010. "At Planned Parenthood, medical abortion is extremely safe," said reproductive health researcher James Trussell from Princeton University in New Jersey, who worked on the study. "The most common adverse outcome is just continuing pregnancy," he added. "It doesn't work 100 percent of the time." The data came from 233,805 first-trimester abortions done using the drugs mifepristone and misoprostol at 317 Planned Parenthood health centers. In one in 200 of those cases, women had an ongoing pregnancy that wasn't terminated after two attempts with medication, the researchers reported Thursday in Obstetrics & Gynecology. Eight women each year had an ectopic pregnancy - when the embryo implants outside the uterus - that was diagnosed after the attempted abortion. One died from related complications. Of the 233,805 abortions during the study period, 385 women had a serious side effect, including 238 who sought ER treatment, 135 who were admitted to the hospital, 114 who had a blood transfusion and 57 who required intravenous antibiotics. All of those women survived. "This continues to show that medical abortion is a very, very safe option for women," said Dr. Debra Stulberg, who studies disparities in reproductive health at the University of Chicago and wasn't involved in the new study. "That's really the take-home point." She told Reuters Health medical abortions are still less common than surgical ones in the U.S., but that they're becoming relatively more frequent and "women should be reassured" based on these and other data. Surgical procedures are also known to be safe, researchers noted. One study from 2010 found that about one percent of women having a surgical abortion before their 16th week of pregnancy had a complication that could require intravenous fluid, and just one in 300 had a major complication. One limitation, the study team noted, is that not all women checked back after the abortion or had follow up medical records available - so it's possible more complications could have occurred that weren't recorded. Planned Parenthood staff members were required to make three attempts to reach any patients who didn't return for follow up visits under the organization's medical standards and guidelines. "We assume that if anything had happened, that people would get back in touch with Planned Parenthood," Trussell told Reuters Health. "The reason that people often skip their follow up is, they're fine." Two of the study's authors are Planned Parenthood employees, and Trussell is a member of the National Medical Committee of Planned Parenthood Federation of America. Another author receives compensation from the U.S. distributor of mifepristone, Danco Laboratories. The medication regimen used by Planned Parenthood - and many other abortion providers - is slightly different than the U.S. Food and Drug Administration-approved drug course because it includes lower doses of mifepristone and at-home use of misoprostol. There have been attempts in some states to force providers to use the approved regimen, according to Trussell, even though so-called off-label use of the drugs is allowed. There's no evidence the FDA regimen is safer, he said - but it is more expensive. "It has nothing to do with medicine," he said. "It's just nuisance." Medical abortions done at Planned Parenthood run for about $300 to $800, according to its website. The researchers said their findings don't support laws restricting the drugs' use. "Mandating the FDA-approved regimen, without a scientific basis, does not protect patients from unsafe abortion; it only limits access to safe and effective medical abortion for women desiring a pregnancy termination," they concluded.

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U.S. food, animal groups seek lower ractopamine limits

Food safety and animal welfare groups petitioned the U.S. Food and Drug Administration on Thursday seeking limits on an animal feed additive that is the subject of concerns about human and animal health. Russia said earlier this month that it was requiring meat it imports to be tested and certified free of the feed additive ractopamine, a move jeopardizing the more than $500 million a year in exports of U.S. beef and pork to that country. U.S. trade authorities have taken a stand against Russia's sudden decision to require that meat imports be documented as free of ractopamine and have urged Russia to suspend such measures. Russia has denied that its action on meat imports was in response to the U.S. Senate including a measure to "name and shame" human rights violators as part of a bill expanding trade with Russia. Ractopamine is fed to animals to accelerate growth and make their meat leaner, but countries such as China have banned its use amid concerns the additive may be harmful to the animals and that traces of the drug could persist in meat products. In their petition to the FDA, the Center for Food Safety and the Animal Legal Defense Fund called for an immediate reduction in the allowable levels of ractopamine and asked FDA to study the long-term effect of human consumption and the impacts on animals associated with ractopamine. "FDA's approval for ractopamine relied primarily on safety studies conducted by the drug-maker, Elanco," the groups said in a statement. "A review of available evidence collected from FDA and the European Food Safety Authority calls FDA's approvals into question." The groups said that ractopamine is fed to an estimated 60 to 80 percent of U.S. pigs, and has resulted in more reports of sickened or dead pigs than any other livestock drug on the market. Ractopamine effects may include toxicity and other exposure risks, such as behavioral changes and cardiovascular, musculoskeletal, reproductive, and endocrine problems, the groups said. About 160 countries ban or restrict ractopamine, including all the nations of the European Union, China, Taiwan, and Russia, the groups said. FDA spokeswoman Shelly Burgess said the agency had extensively evaluated ractopamine before approval and "continues to monitor the safety and effectiveness of animal drugs like ractopamine" after they receive FDA approval. "Twenty-six other countries have also approved ractopamine," Burgess said. All of these countries ... have concluded that food derived from animals treated with ractopamine is safe for humans to eat.

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Enzon Pharma cuts more jobs, to stop drug development

Enzon Pharmaceuticals Inc said it will suspend all clinical development activities, days after the cancer drug developer decided to explore a possible sale. The company, in which activist investor Carl Icahn has a 13.29 percent stake, spent about $4 million last quarter on pipeline research and development and had cash, cash equivalents and marketable securities of $288.7 million as of September 30. It will also reduce its workforce from 43 employees to about 23-28, Enzon said. Last September, it laid off about half its workforce. The biotechnology company has two drugs in mid-stage trials and a number of others in early-stage studies. Enzon, whose revenue mainly comes from royalty payments, will incur about $1.4 million in charges related to the reduction in force and expects to record charges in the first quarter of 2013. Shares of Enzon, which has a market capitalization of about $200 million, closed at $4.50 on Thursday on the Nasdaq.

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Federal appeals court rules against Hobby Lobby on contraception

A federal appeals court on Thursday rejected a claim by an arts and crafts chain that wants to be exempted from a requirement to provide emergency contraceptives to employees because it violates the religious principles of its owners. The Court of Appeals in Denver ruled against family-owned Hobby Lobby's assertion that the religious beliefs of its owners should relieve them from providing the "morning after" and "week after" pills to their employees, as required under President Barack Obama's signature health care reforms. Hobby Lobby vowed to appeal to the U.S. Supreme Court. "The Green family is disappointed with this ruling," said Kyle Duncan, general counsel for the Becket Fund for Religious Liberty, which is assisting Hobby Lobby in the legal case. "The Greens will continue to make their case on appeal that this unconstitutional mandate infringes their right to earn a living while remaining true to their faith." The medications at issue are classified as emergency contraceptives by the Food and Drug Administration, but the owners of Hobby Lobby call them "abortion-inducing drugs" because they are often taken after conception. The lawsuit is among 42 legal actions that have been filed over the issue, according to the Becket Fund for Religious Liberty, a non-profit law firm in Washington, D.C. The company faces fines of up to $1.3 million daily if it disobeys the mandate, which takes effect on January 1 for Hobby Lobby, a $3 billion chain, and its smaller sister operation, Mardel, a Christian-oriented bookstore and educational supply company. Both companies are owned by the Green family of Oklahoma City, whose patriarch, David Green, is ranked 79th on Forbes Magazine's list of the 400 richest Americans, with a net worth of $4.5 billion. The family operates 514 Hobby Lobby stores in 41 states and employ 13,240 people. Inspirational Christian music is played in the stores, which are closed on Sundays. U.S. District Judge Joe Heaton of the Western District of Oklahoma ruled on November 19 that the privately-owned companies are secular, for-profit enterprises that do not possess the same religious rights as the individual members of the family.

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China probes Yum Brands' KFC over safety of chicken products

Yum Brands Inc's fast-food chain KFC was supplied with chicken in China that contained excessive amounts of antibiotics, said food safety authorities investigating allegations of tainted KFC products. The finding by the Shanghai Food and Drug Administration (SFDA) deals a blow to KFC's reputation in China, where it is facing fierce competition from the likes of Taiwanese-owned fried chicken chain Dico and Japanese-style noodle chain Ajisen (China) Holdings Ltd. Yum Brands has forecast a drop in same store China sales in the fourth quarter. Eight of the 19 batches of chicken samples Yum Brands sent to a testing laboratory in 2010 and 2011 contained overly high levels of antibiotics, the SFDA said in a statement on its Website late on Thursday. An investigation is underway to determine whether Yum Brands had taken corrective measures at that time, and the Louisville, Kentucky-based company may face harsh penalties if the probe showed laws had been violated, the SFDA said. Shares in Yum Brands have slumped 4 percent since December 18 when China's state television CCTV reported that some poultry suppliers in eastern Shandong province had fed chickens with anti-viral drugs and hormones to accelerate their growth. The SFDA is looking into the CCTV report and has not released its findings yet, but authorities in Shandong have already shut two chicken farms in eastern China, including one that supplied KFC and McDonald's Corp, the official Shanghai Daily newspaper reported on Thursday. Officials at Yum Brands in China could not be immediately reached for comment. KFC's subsidiary in China has pledged to cooperate with the authorities, while McDonald's wrote on its official microblog that its chicken and raw materials pass through independent, third-party laboratory tests. Shares in Yum Brands, which also owns Pizza Hut and Taco Bell, closed 1 percent lower at $69.49 in New York on Thursday. China has been trying to stamp out health violations that have dogged the country's food sector amid reports of fake cooking oil, tainted milk and even exploding watermelons. In 2008, milk laced with the industrial chemical melamine killed at least six children and sickened nearly 300,000.

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